Wheat, the
Bible tells us, is the “staff of life”. It has been the cornerstone of human
diet since antiquity. For over ten thousand years, wheat has occupied a
prominent place in caves, huts and on modern tables. However, almost all wheat
consumed today bears little resemblance to what our ancestors ate over the
millennia. There the rub.
At the
onset of agriculture, the first farmers planted and harvested a form of wheat
called “Einkorn” (triticum monococcum).
Einkorn had a fairly simple genetic code containing fourteen chromosomes. A
couple of millennia later, the
“Emmer” (triticum dicoccum)
variety of wheat made its appearance. This was a genetic hybrid of Einkorn and
a wild grass called “Goat Grass” (aegilops
speltoides). Emmer was slightly more complex than Einkorn due to its twenty
eight chromosome genetic structure, but still shared most of the genetic traits
of its progenitor. Emmer and Einkorn would be the mainstays of man’s
wheat-dominated diet for thousands of years.
During
latter half of the 20th century, faced with the urgent problem of
feeding the rapidly growing world population, scientists conducted intensive
research into creating a new genetic wheat hybrid that would provide greater
yield, and would be disease, drought, and heat resistant. Thus was born modern
wheat: triticum aestivum. Today,
modern wheat is the most consumed grain on earth and is responsible for twenty percent of all human caloric
consumption. While it is undoubtedly true that this form of wheat prevented
mass starvation in the third world, it is also responsible for some of the most
pernicious chronic degenerative diseases known to man.
Modern
wheat contains forty two chromosomes, which puts it thousands of genes apart
from the einkorn wheat of yore. Einkorn and modern wheat may look and taste the
same, but there are major biochemical differences. Up to 75% of the total
carbohydrate content in modern wheat consists of Amylopectin-A, a compound composed of a chain of glucose units.
This starch is efficiently digested, and causes a sharp rise in blood sugar
levels immediately upon consumption. Its glycemic index (GI) - a measure of how
quickly blood sugar levels rise after eating a type of food - is 72, higher
than sucrose (table sugar: GI 59). High GI foods are directly implicated in
hyperinsulinism, chronic inflammation due to excess deposition of visceral fat
in the body, and the collection of autoimmune conditions commonly known as
Syndrome X. In his bestselling book “Wheat Belly”, Dr. William Davis notes that
while wheat and diabetes have travelled hand in hand throughout most of
history, the arrival of modern wheat has precipitated an explosion in the rate
of diabetes around the world today.
Other
insidious effects of modern wheat are caused by the very component that gives
it its unique cohesiveness and malleability: the protein Gluten. In about 1 in
100 people (98% of whom have the generic markers HLA-Q2 or DQ8), gluten
triggers an immune response characterized by severe inflammation of the small
intestine. This is manifested by incapacitating abdominal cramps, diarrhea,
bloating and fatigue (see table 1), a collection of symptoms widely known as
Celiac disease. If left untreated, this condition has been shown to severely
damage intestinal walls. Celiac disease has been recognized and treated by the
medical community for several decades. However, gluten is also responsible for
another, less recognized condition known as non-Celiac gluten sensitivity,
which has very Celiac-like symptoms (see table 1). This condition lacks the
immune response, intestinal damage and genetic markers of celiac disease, but
is linked to severe neurologic and psychiatric conditions including
schizophrenia and cerebellar ataxia.
Gluten
works its nefarious ways by stimulating the intestines to produce a protein
called Zonulin. Zonulin damages the gut lining by breaking up the tight
junctions between the intestinal cells thereby causing a leaky gut. As a
result, partially digested food and intestinal microbes cross the gut barrier
and enter the bloodstream. This exposure triggers an immune reaction,
generating antibodies that attack the body’s own tissue leading to systemic
inflammation. Various conditions such as heart disease, dementia, cancer and
diabetes are linked to systemic inflammation.
Another
alarming aspect of gluten is that when exposed to stomach acid and enzymes, it
gets digested into shorter proteins or polypeptides called exorphins. These are
like endorphins that one gets from an exercise high. The exorphins can cross the blood brain barrier and bind to
opioid receptors in the brain. These are the same receptors to which opiates
such as heroin bind. Wheat exorphins behave exactly like a drug causing
multiple problems with brain physiology including schizophrenia and autism.
They also cause addictive behavior including cravings and binge eating. Thus
gluten can alter mood and generate withdrawal symptoms upon its elimination.
Beyond
gluten, there are about 20% non-gluten proteins can cause allergic or
anaphylactic reactions in human (see table 1). Some of these non-gluten
proteins include agglutinins, alpha amylases, thioredoxin and
glycerinaldehyd-3-phosphare dehydrogenases. Exposure of these elements triggers
asthma, rashes and wheat-dependent exercise-induced anaphylaxis (WDEIA) in
susceptible individuals.
Strict
elimination of gluten is the most effective way to reverse all the above
conditions. A gluten-free lifestyle is also recommended for ostensibly healthy
individuals because the majority of individuals who are sensitive to wheat may
not exhibit any visible problems. Yet when they cut wheat out of their diets,
they experience health benefits that include better mood, clearer skin, less
fatigue, clearer thinking. Gluten elimination also helps those who struggle
with autoimmune diseases, mental disorders, migraines, eczema and psoriasis,
and joint pain. If you are suffering from any of the issues listed below it may
be worthwhile to try a gluten free diet for a period of six weeks.
1) Genetic
predisposition or a family history
of celiac disease or gluten intolerance
2) Presence
of any digestive disease such as irritable bowel syndrome, colitis, poor
intestinal permeability
3) Presence
of food sensitivities that manifest as migraines, chronic fatigue, aches and
pains, skin problems such as eczema, acne or pityriasis,
4) Presence
or a family history of autoimmune conditions such as diabetes, rheumatoid
arthritis and lupus.
5)
Difficulty in losing weight.
Table 1:
Some of the symptoms associated with celiac disease, wheat allergy and non
celiac gluten sensitivity
|
Celiac Disease
|
Wheat Allergy
|
Non celiac gluten sensitivity
|
Gastrointestinal
|
Abdominal pain
Diarrhea
Constipation
|
Abdominal pain
Diarrhea
Vomiting
|
Abdominal pain
Diarrhea
Constipation
Nausea
Vomiting
|
Neurologic or
psychiatric
|
Headache
Brain fog
Fatigue
Numbness
in hand and feet
Musculoskeletal
pain
Ataxia
|
Dizziness
Headache
|
Headache
Brain fog
Fatigue
Numbness
in hand and feet
Musculoskeletal
pain
Other
neurologic and psychiatric conditions
|
Other
|
Dermatitis herpetiformis
Weight loss
|
Eczema
Asthma
Rhinitis
Nausea
Itchiness
|
Rash
Nausea
Weight loss
|